Search Results - oncology+(small+molecules%2c+peptides+and+antibodies)

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Inhibitors of the N-terminal Domain of the Androgen Receptor (UCLA Case No. 2023-075)

Researchers at UCLA under the guidance of Drs. Matthew Rettig and Michael Jung have developed novel molecular compounds that reduce growth of prostate cancer cells. Dr. Jung in collaboration with Dr. Rettig have furthered the development of these compounds by synthesizing a new series of analogues that have similar inhibitory effects. BACKGROUND: Prostate...

Published: 9/23/2024 | Inventor(s): Matthew Rettig, Michael Jung

Keywords(s): androgen receptor therapy, castration resistant prostate cancer, Oncology, Oncology (Small Molecules, Peptides and Antibodies), prostate cancer, small molecules

Category(s): Therapeutics > Oncology, Therapeutics > Oncology > Oncology (Small Molecules)

Antitumor activity of NKTR-214 alone or in combination with anti-PD-1 therapy in tumors resistant to anti-PD-1 (UCLA Case No. 2019-254)

UCLA researchers have discovered a therapy for anti-PD-1 resistant tumors in colon carcinoma patients. A small molecule therapeutic alone or in combination with immune-checkpoint blockade (ICB) therapy exhibits tumor remission even in sublines with mutated signalling pathways that have rendered them ICB resistant. BACKGROUND: Immunotherapy, the...

Published: 2/15/2024 | Inventor(s): Antoni Ribas

Keywords(s): Colon carcinoma, Immune checkpoint blockade, Immunotherapy, Oncology, Oncology (Small Molecules, Peptides and Antibodies), PD-1, PD-L1, Resistant tumors, Signaling pathways, Small molecule therapeutics, Tumor

Category(s): Life Science Research Tools, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Oncology > Oncology (Small Molecules)

Impaired Nucleotide Catabolism Renders Cancer Cells Sensitive to PNP Inhibition

UCLA researchers in the Department of Molecular and Medical Pharmacology have uncovered novel biomarkers to predict cancer sensitivity to PNP inhibitors. BACKGROUND: A common hallmark of cancer is the alteration of cellular metabolism. To sustain growth and proliferation, cancer cells must produce sufficient and balanced pools of deoxyribonucleotide...

Published: 7/19/2023 | Inventor(s): Caius Radu, Evan Abt, Thuc Le

Keywords(s): Oncology (Small Molecules, Peptides and Antibodies)

Category(s): Therapeutics > Oncology > Oncology (Small Molecules)

2015-341 COMBINATIONS OF CHECKPOINT INHIBITORS AND DENDRITIC CELL VACCINES TO TREAT BRAIN CANCER

UCLA researchers in the Departments of Neurosurgery and Molecular and Medical Pharmacology have developed an autologous dendritic cell (DC) vaccine in combination with checkpoint inhibitors for the treatment of malignant brain tumors.BACKGROUND: Checkpoint inhibitor therapies, which unblock an existing immune response, or unblock the initiation of an...

Published: 7/19/2023 | Inventor(s): Robert Prins, Linda Liau

Keywords(s): Antibodies, Drug Delivery, Immunotherapy, Oncology, Oncology (Small Molecules, Peptides and Antibodies), Oncology Immunotherapy, Therapeutics & Vaccines, Vaccines

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Vaccines, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Oncology > Oncology (Small Molecules)

2012-601 Development of a New Approach to Kill Human Non-Small Cell Lung Cancer Stem Cells

Novel Small Molecules that Target Cancer Stem Cells for the Treatment of CancerBACKGROUNDLung cancer is the leading cause of cancer related death in the United States. In 2012, it is estimated that approximately 230,000 patients will be newly diagnosed, and since more than 160,000 individuals will succumb to this disease, there exists an urgent need...

Published: 7/19/2023 | Inventor(s): Michael Jung, Richard Pietras, Diana Marquez Garban, Gang Deng

Keywords(s): Oncology (Small Molecules, Peptides and Antibodies), Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Oncology > Oncology (Small Molecules)

2019-318 NONCOVALENT METHODS TO MODIFY BIOMOLECULES

INTRO SENTENCE:UCLA researchers in the Department of Chemistry and Biochemistry have designed a novel method for the sequential detection and treatment of diseases.BACKGROUND:In most clinics, the general approach to helping new patients involves two separate steps – diagnosis and treatment. The separation of treatment from diagnosis necessitates...

Published: 7/19/2023 | Inventor(s):

Keywords(s): All Types, Animal Imaging, Diagnostic Markers & Platforms, Life Science Research Tools, Medical Imaging, Oncology (Small Molecules, Peptides and Antibodies)

Category(s): Life Science Research Tools > Animal Imaging, Life Science Research Tools, Diagnostic Markers, Medical Devices > Medical Imaging, Therapeutics > Oncology > Oncology (Small Molecules)

2015-811 MI-181: A Potent Small Synthetic Microtubule-Targeting AntiCancer Agent

MI-181: A Potent Small Synthetic Microtubule-Targeting Anticancer AgentSUMMARYUCLA researchers in the Department of Chemistry & Biochemistry and Department of Molecular & Medical Pharmacology have discovered compound MI-181 and successfully synthesized its derivatives and analogs, which have the potential for use in cancer therapy by arresting...

Published: 7/19/2023 | Inventor(s): Robert Damoiseaux, Jorge Torres, Todd Yeates, Dan Mcnamara, Silvia Senese

Keywords(s): Oncology, Oncology (Small Molecules, Peptides and Antibodies), Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Oncology, Therapeutics > Oncology > Oncology (Small Molecules)

2014-387 Small Molecule Antagonists of the Pro-Survival Protein MCL-1 (POC 2016)

Small Molecule Antagonists Of The Pro-Survival Protein Mcl-1SUMMARYUCLA Researchers have discovered novel inhibitors to signaling proteins involved in the regulation of apoptosis. MCL-1, which is known to be overexpressed in many cancers, is believed to be upregulated in cancers to prevent the apoptosis pathway.The researchers have developed novel small...

Published: 7/19/2023 | Inventor(s): Patrick Harran, Gordon Shore, James Frederich, Mai Nguyen

Keywords(s): Oncology, Oncology (Small Molecules, Peptides and Antibodies), Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Oncology, Therapeutics > Oncology > Oncology (Small Molecules)

2009-221 Small Molecule Modulators of Mitochondrial Protein Import (MitoBloCK1)

Small Molecule Modulators Of Mitochondrial Protein ImportSUMMARYUCLA researchers in the Department of Chemistry & Biochemistry have discovered a set of small molecules that modulate the protein translocation across the mitochondrial membranes, which in turn controls the assembly and function of the mitochondria.BACKGROUNDMitochondria are rod-shaped...

Published: 7/19/2023 | Inventor(s): Carla Koehler, Samuel Hasson

Keywords(s): Oncology (Small Molecules, Peptides and Antibodies), Therapeutics & Vaccines

Category(s): Therapeutics, Therapeutics > Oncology > Oncology (Small Molecules)

Epitopes for Detection of Antibodies Against Tumor Antigens

Case 2004-496UCLA researchers have developed a new product for the detection, prognosis and prediction of multiple cancers based on the simultaneous detection of serum antibodies to multiple tumor-associated antigens. The method bypasses the expensive and difficult requirement for purification of individual recombinant TAA proteins by using chemically...

Published: 7/19/2023 | Inventor(s): Gang Zeng

Keywords(s): Immunology, Immunotherapy, Oncology, Oncology (Small Molecules, Peptides and Antibodies), Oncology Immunotherapy, Therapeutics & Vaccines

Category(s): Diagnostic Markers > Immunology, Therapeutics, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Oncology > Oncology (Small Molecules)

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