Search Results - platforms+%3e+drug+delivery

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In Cellulo Synthesis of mRNA-Specific Stoichiometrically-Precise Virus-Like Particles (UCLA Case No. 2024-056)

UCLA researchers from the Department of Chemistry and Biochemistry have developed a novel virus-like particle (VLP) platform for the encapsulation of mRNA for efficient therapeutic delivery. BACKGROUND: Messenger RNA (mRNA) technologies have emerged as powerful therapeutics in vaccines and gene therapies. While traditional methods of mRNA therapeutics...

Published: 12/8/2025 | Inventor(s): William Gelbart

Keywords(s):

Category(s): Therapeutics > Vaccines, Platforms > Drug Delivery, Therapeutics > Gene Therapy And Editing, Materials > Nanotechnology

Nanoparticle & dsDNA Toolkit for Decreased Toxicity and Gene Editing of Epithelial Stem Cells via Epithelial Disruption (UCLA Case No. 2023-205/209) -- for Cystic Fibrosis and other genetic diseases

UCLA researchers in the Department of Pediatrics, Hematology/ Oncology have constructed a nanoparticle toolkit for increased integration and reduced toxicity for gene therapies that treat debilitating diseases such as Cystic Fibrosis and other critical genetic diseases. BACKGROUND: Gene therapies are the forefront of therapeutic advancements as a one-off...

Published: 12/1/2025 | Inventor(s): Steven Jonas, Brigitte Gomperts, Donald Kohn

Keywords(s):

Category(s): Therapeutics > Gene Therapy And Editing, Platforms > Drug Delivery

Hyperbranched Polyglycerol Encapsulated Proteins for Oral Protein Delivery (Case No. 2012-425)

Patent Abstract: Methods for modifying therapeutic agents such as therapeutic biomolecules, such as proteins for improved oral, rectal or transmucosal delivery, as well as compositions made using such methods and methods of administering such compositions to a subject, are disclosed. Specifically, the therapeutic agents are conjugated to hyperbranched...

Published: 12/1/2025 | Inventor(s): Yunfeng Lu, Juanjuan Du, Jie Li, Yang Liu

Keywords(s):

Category(s): Platforms > Drug Delivery

Pancreas Cancer Immunotherapy using Cationic Lipid and Polymer Nanocarriers for co-delivery of KRAS Neoantigens and STING or other immunomodulators to boost the Cancer Immunity Cycle and Treat Liver Metastasis (UCLA Case No. 2024-076)

UCLA researchers have developed a translational immunotherapy platform that leverages nanoparticle-based delivery of tumor-associated signals and immune-stimulatory molecules to drive localized immune activation in metastatic pancreatic cancer. This approach is designed to initiate de novo immune priming and recondition the tumor microenvironment in...

Published: 10/29/2025 | Inventor(s): Andre Nel

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Vaccines, Platforms > Drug Delivery

Mucus Targeting Particles (MTPs) Technology for Sustained Drug Delivery Applications (UCLA Case No. 2020-809)

UCLA researchers in the Department of Chemical and Biomolecular Engineering have developed a robust nanoparticle technology for effective, sustained-release ocular drug delivery. BACKGROUND: Topically applied therapeutics are the common mode of delivery for treating ocular diseases, ranging from chronic conditions like glaucoma to acute inflammation...

Published: 10/24/2025 | Inventor(s): Nasim Annabi, Shima Gholizadeh, Reza Dana

Keywords(s):

Category(s): Therapeutics > Ophthalmology, Materials > Nanotechnology, Platforms > Drug Delivery

Synthetic Cannabinoid WIN 55,212-2 Increased the Cytotoxicity of NK Cells and IFN-gamma Secretion Ability of Immune Cells in Humanized BLT Mouse Model (UCLA Case No. 2022-281)

UCLA researchers in the School of Dentistry have developed novel strategies synergizing the anti-tumor effects of a synthetic cannabinoid, cytokine, and probiotic bacteria to augments NK cell mediated functions and target a wide variety of cancers and viral infections. BACKGROUND: Interest in the use of synthetic cannabinoids for the treatment of disease...

Published: 10/23/2025 | Inventor(s): Anahid Jewett

Keywords(s):

Category(s): Platforms > Drug Delivery, Therapeutics > Oncology > Oncology Immunotherapy

A Glucose-Responsive Glucagon-Micelle for the Prevention of Hypoglycemia (UCLA Case No. 2024-161)

Contact UCLA Technology Development Group to learn more. More information available soon. Keywords: drug delivery, nanomedicine, nanocarriers, Polymeric Micelles

Published: 10/2/2025 | Inventor(s): Heather Maynard

Keywords(s):

Category(s): Platforms > Drug Delivery

Method of Creating Hydrogels Through Oxime Bond Formation (UCLA Case No. 2013-180)

UCLA researchers led by Professor Heather Maynard in the Department of Chemistry have developed a method for creating hydrogels using a patented and specific type of chemical reaction called oxime bond formation (or oxime ligation). BACKGROUND: While many methods exist to create hydrogels (cross-linked materials used in biomedicine), most suffer from...

Published: 10/2/2025 | Inventor(s): Heather Maynard, Tatiana Segura, Gregory Grover, Jonathan Lam

Keywords(s):

Category(s): Platforms > Drug Delivery, Therapeutics > Oncology, Chemical > Polymers

Interactive Systems and Methods for Identifying Target Proteins in Drug Discovery (Case No. 2025-098)

Summary: UCLA researchers from the Department of Electrical and Computer Engineering have developed a novel computational system for target protein identification, enabling integrative drug discovery. Background: Target identification (Target ID) in drug discovery involves the identification and evaluation of protein candidates that could interact...

Published: 10/1/2025 | Inventor(s): Xiang Chen, Youngseung Jeon, Christopher Hwang, Ziwen Li, Jesus Campagna, Varghese John, Whitaker Cohn, Eunice Jun

Keywords(s): AI-driven drug discovery, Alzheimer’s disease target discovery, Bioinformatics software platform, Drug, Drug Discovery, Functional annotation of proteins, High-throughput docking, large language models (LLMs), Ligand-protein docking, Mechanism-of-action prediction, Molecular docking simulation, Multi-criteria decision support, Neurodegenerative disease therapeutics, Pathway-centric drug targeting, personalized medicine, PPI-Comparator, PPI-Explorer, Protein structure prediction, Protein-protein interaction (PPI) analysis, Rational drug design, Retrieval-augmented generation (RAG), Semantic similarity modeling, Small molecule screening, Systems biology interface, Target identification (Target ID), Therapeutic impact modeling, User-guided AI exploration

Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Digital Health, Life Science Research Tools, Life Science Research Tools > Research Methods, Platforms, Platforms > Drug Delivery

Glucagon Conjugated Trehalose Diblock Copolymers and Methods of Use (UCLA Case No. 2024-283)

UCLA researchers from the Department of Medicine-Endocrinology have formulated a novel nanoparticle for management of hypoglycemia that can efficiently deliver glucagon, while also allowing for long-term stabilization and storage. BACKGROUND: Hypoglycemia is a condition characterized by abnormally low blood glucose levels, posing a significant risk...

Published: 12/9/2025 | Inventor(s): Heather Maynard

Keywords(s):

Category(s): Platforms > Drug Delivery, Chemical > Polymers, Therapeutics > Metabolism And Endocrinology

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