Search Results - therapeutics+%3e+cns+and+neurology

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Novel Biomarkers for Sanfilippo Syndrome (UCLA Case No. 2024-150)

UCLA researchers from the Department of Neurology have identified novel biomarkers of Sanfilippo Syndrome, leading to potential minimally invasive methods to detect Sanfilippo Syndrome and assess clinical trial outcomes. More information to follow. Contact UCLA Technology Development Group if you would like to learn more in the meantime.

Published: 6/3/2026 | Inventor(s): Gal Bitan

Keywords(s):

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Metabolism And Endocrinology, Diagnostic Markers > Targets And Assays

Microbial de Novo Biosynthesis of Rare Cannabinoids (UCLA Case No. 2025-200)

Please contact UCLA Technology Development Group if you're interested in learning more. More info available soon.

Published: 6/2/2026 | Inventor(s): ikechukwu okorafor

Keywords(s):

Category(s): Therapeutics > Cardiovascular, Therapeutics > CNS and Neurology

Device and Method for Recording-Guided Neuromodulation via the Olfactory Cleft (Case No. 2026-077)

Summary: UCLA researchers in the Department of Neurology have developed a minimally invasive, recording-guided closed-loop neuromodulation device enabling transnasal access to olfactory-cleft pathways for targeted modulation of deep limbic brain circuits. Background: The olfactory bulb provides direct anatomical and functional pathways to the limbic...

Published: 6/3/2026 | Inventor(s): Kevin Bickart, Mahmoud Omidbeigi

Keywords(s): Brain, Deep Brain Stimulation, Deep Brain Stimulation Current Mirror Output Impedance, device stability, Electrical Brain Stimulation, Electrical stimulation, minimally invasive device, neural stimulation, Neuromodulation, Neurostimulation, noninvasive, non-invasive, non-invasive monitoring, Transcutaneous Electrical Nerve Stimulation

Category(s): Software & Algorithms > Bioinformatics, Therapeutics > CNS and Neurology, Software & Algorithms > Digital Health, Electrical, Life Science Research Tools, Medical Devices, Medical Devices > Monitoring And Recording Systems, Medical Devices > Neural Stimulation

Enhanced Therapeutic Effect of Armored CAR-T Cells for the Treatment of Glioblastoma (UCLA Case No. 2024-066)

UCLA researchers from the Department of Microbiology, Immunology, and Molecular Genetics have engineered chimeric antigen receptor (CAR)-T cells that co-express defined immunostimulatory cytokines to enhance therapeutic efficiency against glioblastoma (GBM). BACKGROUND: Glioblastoma Multiforme (GBM) is the most common primary malignant brain tumor...

Published: 5/1/2026 | Inventor(s): Yvonne Chen

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > CNS and Neurology

Linking the Gap Between Traumatic Brain Injuries & Cognitive Impairments Through the Creation of Machine Learning Based Diagnostic & Prognostic Clinic (Case No. 2026-251)

Summary: UCLA researchers have developed a machine learning-based clinical decision support tool that predicts patient-specific cognitive impairments following traumatic brain injury (TBI) using neuroimaging and multimodal clinical data. The software leverages MRI-derived structural brain information to generate individualized diagnostic and prognostic...

Published: 5/1/2026 | Inventor(s): Sonya Ashikyan, Martin Monti, Jeffrey Chiang

Keywords(s):

Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Digital Health, Software & Algorithms > Bioinformatics, Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > CT, Medical Devices > Medical Imaging > MRI, Therapeutics > CNS and Neurology, Therapeutics

Active Electromagnetic Interference Suppression for Magnetic Resonance Imaging-Guided Interventions (Case No. 2026-217)

Summary: UCLA researchers in the Department of Radiological Sciences have developed a software-based active electromagnetic interference suppression solution for real-time MRI-guided interventions. Background: Microwave ablation (MWA) has emerged as the preferred thermal ablation modality for treating non-surgical patients with primary and metastatic...

Published: 4/16/2026 | Inventor(s): Holden Wu, Qing Dai

Keywords(s):

Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Image Processing, Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > MRI, Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Lab Equipment, Medical Devices > Monitoring And Recording Systems, Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Inflammation And Inflammatory Diseases, Mechanical, Mechanical > Instrumentation, Mechanical > Sensors, Electrical, Electrical > Electronics & Semiconductors, Electrical > Signal Processing, Electrical > Instrumentation, Electrical > Imaging

UCHL1 Inhibitors, Modifications, and Uses Thereof (UCLA Case No. 2026-123)

UCLA researchers in the Department of Molecular & Medical Pharmacology and have developed novel, highly potent small-molecule inhibitors of UCHL1 that selectively suppress tumor growth and metastasis in aggressive cancers with favorable in vivo safety profiles. BACKGROUND: Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) is a dual-function enzyme...

Published: 3/11/2026 | Inventor(s): Tanya Stoyanova, Michael Jung

Keywords(s):

Category(s): Diagnostic Markers > Cancer, Therapeutics > Oncology, Therapeutics > CNS and Neurology, Therapeutics > Oncology > Oncology (Small Molecules)

Engineered Gamma Delta T-Cells and Methods of Making and Using Thereof (UCLA Case No. 2020-913)

UCLA researchers in the Department of Molecular Immunology & Molecular Genetics have developed gamma delta (gd) T cell receptor gene-modified immune cells derived from stem and progenitor cells that enable scalable, off-the-shelf allogeneic cell therapies with broad therapeutic potential. BACKGROUND: Cell-based immunotherapies have demonstrated...

Published: 3/4/2026 | Inventor(s): Lili Yang, Derek Lee, Tyler Halladay

Keywords(s):

Category(s): Diagnostic Markers > Immunology, Diagnostic Markers > Cancer, Life Science Research Tools > Cell Lines, Therapeutics > Oncology, Therapeutics > CNS and Neurology, Therapeutics > Hematology, Therapeutics > Autoimmune, Therapeutics > Gene Therapy And Editing, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Infectious Diseases

NPEPPS Enhancers for Treating Tau-Induced Neurodegeneration (UCLA Case No. 2018-161)

UCLA researchers from the Department of Neurology have developed first-in-class small-molecule activators of NPEPPS that effectively lower pathological tau, offering a novel disease-modifying strategy for Alzheimer’s and other neurodegenerative disorders. BACKGROUND: Neurodegenerative dementias such as Alzheimer’s Disease (AD) and progressive...

Published: 10/22/2025 | Inventor(s): Daniel Geschwind, Robert Damoiseaux, Liting Deng, Michael Jung, Jennifer Murphy, Gaoyuan Ma

Keywords(s):

Category(s): Therapeutics > CNS and Neurology, Diagnostic Markers > Targets And Assays

Brain Repair in Vascular Dementia and Stroke with A3AR (UCLA Case No. 2024-220)

UCLA researchers from the Department of Neurology have discovered and validated intercellular signaling pathways that can be therapeutically targeted to drive repair and functional recovery in vascular dementia. BACKGROUND: Vascular dementia (VaD) is the second leading cause of dementia and is driven by ischemic injury to cerebral white matter, producing...

Published: 10/14/2025 | Inventor(s): Stanley Carmichael

Keywords(s):

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Cardiovascular, Life Science Research Tools > Animal Models

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