Search Results - therapeutics+%3e+cns+and+neurology

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Mechanical Cutaneous Nerve Stimulation for Reducing Epileptic Seizures and Perceived Pain (Case No. 2016-686-3)

Summary: UCLA researchers have developed a novel, non-invasive pain management device that uses mechanical vibrations to activate cutaneous sensory fibers, reducing epileptic seizures, masking pain perception and alleviating associated symptoms. Background: Unexpected death due to epilepsy is a pressing concern, with an estimated incidence of 1.2...

Published: 4/1/2025 | Inventor(s): Ronald Harper, Eberhardt Sauerland, Christopher Degiorgio

Keywords(s): low-power device, Medical Device, Medical Devices and Materials, minimally invasive device, Neuropathology, Neurostimulation, non-invasive, Pain Treatment, sample-to-answer devices, Semiconductor Device, Smart medical device, Stroke, Transcutaneous Electrical Nerve Stimulation, Vibration monitoring, Vibration sensing, wearable medical device, wearable medical devices

Category(s): Medical Devices, Medical Devices > Monitoring And Recording Systems, Medical Devices > Neural Stimulation, Medical Devices > Hospital Systems, Therapeutics, Therapeutics > CNS and Neurology

Viral Vector-Based Gene Therapy for OPA1 Gene Mutation-Induced Dominant Optic Atrophy (UCLA Case No. 2025-004)

UCLA researchers in the Department of Ophthalmology have developed a viral vector-based gene therapy to restore OPA1 protein levels in patients with OPA1-mutated dominant optic atrophy. The optimized vectors will be delivered intravitreally to patients’ eyes, providing a minimally invasive, effective treatment with reduced side effects. BACKGROUND:...

Published: 3/6/2025 | Inventor(s): Xianjie Yang

Keywords(s): Adeno-associated viruses (AAV), disease model, dominant optic atrophy, Gene Therapy, intravitreal delivery, Lentivirus Viral Vector, mitochondria, mutation, Neuron, OPA1, Ophthalmology, pluripotent stem cell (PSC), retinal ganglion cell

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Gene Therapy And Editing, Therapeutics > Ophthalmology

Manipulating the Gut Microbiome To Modify Host Eating Behavior (UCLA Case No. 2024-181)

UCLA researchers from the Department of Integrative Biology & Physiology have identified aspects of gut microbiome metabolism that affect host eating behavior, leading to possible microbiome therapies for appetite regulation. BACKGROUND: The microbiome consists of all microbes within the human body and has recently been shown to influence human...

Published: 2/26/2025 | Inventor(s): Elaine Hsiao

Keywords(s):

Category(s): Therapeutics > Gastroenterology, Therapeutics > CNS and Neurology, Therapeutics > Metabolism And Endocrinology

Synthetic Exosomes (SE) for CNS Delivery of CRISPR for Gene Editing in Brain Disorders (UCLA Case No. 2021-363)

UCLA researchers from the Department of Neurology have developed synthetic exosomes, a novel delivery technology capable of transporting gene-editing tools and therapeutics across the blood-brain barrier, with successful applications in repairing Alzheimer’s-related mutations and delivering proteins, antibodies, and drugs. BACKGROUND: The emergence...

Published: 2/18/2025 | Inventor(s): Varghese John

Keywords(s): Alzheimers disease, CRISPR, delivery system, exosome, Nanotechnology, nanovesicles, synthetic biology

Category(s): Life Science Research Tools > Microfluidics And Mems, Materials > Nanotechnology, Platforms > Drug Delivery, Therapeutics > Gene Therapy And Editing, Therapeutics > CNS and Neurology

Positive Unlabeled Learning With Bias Mitigation for Fair Prediction of Undiagnosed Alzheimer’s Disease (Case No. 2025-113)

Summary: UCLA researchers in the Department of Neurology have developed a software to predict the diagnosis of Alzheimer’s Disease without racial or ethnic biases. Background: Alzheimer’s Disease (AD) represents a major health and economic challenge in the United States. Despite its prevalence, Alzheimer’s remains significantly...

Published: 2/14/2025 | Inventor(s): Timothy Chang

Keywords(s): Alzheimers disease, artificial intelligence/machine learning models, electronic health records (EHR), medical bias reduction, Neurodegeneration Alzheimer's Disease Predictive Testing, neurological disorders, Neurology, personalized medicine

Category(s): Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Data Analytics, Software & Algorithms > Digital Health, Software & Algorithms > Image Processing, Software & Algorithms > Programs, Diagnostic Markers > Aging, Therapeutics > CNS and Neurology

Microbial Metabolites for Promoting Brain Health (UCLA Case No. 2024-196)

UCLA researchers in the Department of Integrative Biology and Physiology have developed a maternal supplementation with microbiome-dependent metabolites to promote growth and neurobehavioral health in children impacted by maternal protein undernutrition. BACKGROUND: Protein undernutrition poses a significant risk of childhood stunting, accompanying...

Published: 2/14/2025 | Inventor(s): Elaine Hsiao

Keywords(s): Brain, brain health, growth defects, malnutrition, maternal supplementation, microbial metabolites, microbiome, neurobehavioral impairment, neurodevelopment, nutrition, protein undernutrition, stunting

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Gastroenterology, Therapeutics > Psychiatry And Mental Health

Interferon Activation Score Is a Biomarker for Immunotherapy in Malignant Glioma Patients (UCLA Case No. 2024-043)

UCLA researchers from the Department of Neurosurgery have characterized immune responses in malignant glioma patients receiving immunotherapy to develop a robust biomarker that will allow prediction of clinical outcomes following treatment. BACKGROUND: Malignant gliomas are the most common primary brain tumors in adults. No cures exist and most gliomas...

Published: 2/14/2025 | Inventor(s): Robert Prins

Keywords(s): adjuvant therapy, Biomarker, Chemotherapy, Clinical Trial, dendritic cell vaccination, Glioblastoma, Glioma, immune response, Immunotherapy, interferon, malignant glioma

Category(s): Diagnostic Markers > Immunology, Diagnostic Markers > Cancer, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Oncology, Therapeutics > CNS and Neurology

Dissecting Microbiota-Gut-Brain Interactions for the Anti-Seizure Effects of the Ketogenic Diet (UCLA Case No. 2025-006)

UCLA researchers from the Department of Integrative Biology & Physiology have identified specific components of ketogenic diets that alter the microbiome and improve seizure resistance, providing valuable data to optimize diet treatments for refractory epilepsy. BACKGROUND: Refractory epilepsy, a disease characterized by uncontrolled seizures,...

Published: 2/14/2025 | Inventor(s): Elaine Hsiao

Keywords(s): diet, dietary fiber, Epilepsy, gut, gut-brain axis, ketogenic diet, microbiome, pediatrics, seizure

Category(s): Therapeutics > Gastroenterology, Therapeutics > CNS and Neurology, Therapeutics > Metabolism And Endocrinology

Nisin-Based Formulations for Oral and Systemic Conditions (UCLA Case Nos. 2023-133 and 2022-306)

UCLA researchers in the Department of Dentistry have found a novel use for nisin alone, and in formulations, for use in the treatment of Alzheimer’s disease, and multiple inflammation states such as brain inflammation, joint inflammation, oral inflammation, systemic inflammation, inflammatory bowel diseases, and non-alcoholic fatty liver disease...

Published: 2/14/2025 | Inventor(s): Yvonne Kapila

Keywords(s): Alzheimers disease, Antibacterial, gut inflammation, Inflammation, microbiome, nanoparticle delivery system, Nanoparticles, nisin, oral inflammation, periodontal disease, periodontal inflammation, periodontal regeneration

Category(s): Therapeutics > CNS and Neurology

A Tissue-Like Multimodal Neural Probe (Case No. 2024-108)

Summary: UCLA researchers in the Department of Materials Science and Engineering have developed a novel self-softening and biocompatible polymer to be used in a neural probe. Background: Implantable bioelectronics are revolutionizing the diagnosis and treatment of neurological and neuropsychiatric disorders. Compared with noninvasive approaches,...

Published: 3/7/2025 | Inventor(s): Anne Andrews, Qibing Pei, Zhixin Xie, Chuanzhen Zhao

Keywords(s): bioelectronics, neural stimulation, Neuroimaging, Neurointervention, neurological disorders, Neuromodulation, Neuropsychological Test, Polymer, Smart Material, soft robotics, thermal stability, Tissue (Biology)

Category(s): Chemical, Chemical > Polymers, Medical Devices > Neural Stimulation, Therapeutics > CNS and Neurology, Materials > Nanotechnology

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