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Search Results - therapeutics+%3e+oncology+%3e+oncology+immunotherapy
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Methods to Improve Chimeric Antigen Receptor (CAR)-T Cell Efficacy Through Rational Sequence and Structural Modifications (UCLA Case No. 2020-497)
UCLA researchers in the Department of Microbiology, Immunology & Molecular Genetics have developed novel engineering methodologies for CAR molecules that overcome the tonic signaling process that leads to T cell exhaustion and poor therapy efficacy. Background: Immunotherapy has become a highly effective method to combat cancer that enhances a...
Published: 2/14/2025
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Inventor(s):
Yvonne Chen
Keywords(s):
Cancer Immunotherapy
Category(s):
Therapeutics > Oncology > Oncology Immunotherapy
Functional Enrichment and Purification of a Therapeutically Superior Population of Cells (Case No. 2024-024)
Summary: UCLA researchers in the Departments of Bioengineering and Biological Chemistry have developed a method for identifying and enriching therapeutically useful cell sub-populations based on their secretions (SEC-seq). Background: Cell function is defined by a myriad of biomolecules that they secrete; over 3 thousand proteins are estimated to...
Published: 3/3/2025
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Inventor(s):
Dino Di Carlo
,
Kathrin Plath
,
Shreya Udani
,
Justin Langerman
Keywords(s):
Cell Surface Receptor
,
Cytometry
,
Flow Cytometry
,
Functional Genomics
,
High-Throughput Screening
,
hydrogel
,
Microfluidics
,
single cell analysis
,
Therapeutics
Category(s):
Therapeutics > Immunology And Immunotherapy
,
Therapeutics
,
Therapeutics > Oncology > Oncology Immunotherapy
,
Life Science Research Tools
,
Life Science Research Tools > Research Methods
,
Diagnostic Markers > Targets And Assays
,
Therapeutics > Cell Therapy
Inhibitory Chimeric Antigen Receptors That Reduce Car-T Cell “On-Target, Off-Tumor” Toxicity (UCLA Case No. 2022-186)
SUMMARY: UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics, and the Department of Molecular and Medical Pharmacology have recently developed a novel approach which improves the kinetics and specificity of CAR T-cell therapy. BACKGROUND: Chimeric antigen receptor (CAR) T-cell therapy makes use of reengineered...
Published: 2/14/2025
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Inventor(s):
Owen Witte
Keywords(s):
blood cancers
,
CAR-T cell therapy
Category(s):
Therapeutics > Immunology And Immunotherapy
,
Therapeutics > Oncology
,
Therapeutics > Oncology > Oncology Immunotherapy
,
Therapeutics
Inhibition of BMI1 Eliminated Cancer Stem Cells and Activates Antitumor Immunity (UCLA Case No. 2020-858)
UCLA researchers in the Department of Dentistry discovered that targeting BMI1in head and neck squamous cell carcinoma (HNSCC) may be a viable immune checkpoint to inhibit metastatic tumor growth, and prevent tumor relapse through activation of cell-intrinsic immunity and purging cancer stem cells (CSCs). BACKGROUND: Cancer stem cells are cancer...
Published: 2/14/2025
|
Inventor(s):
Cun Yu Wang
,
Jia Lingfei
Keywords(s):
Cancer stem cells
,
Epigenetics
,
Immunooncology
,
Oncology Immunotherapy
,
Tumor
Category(s):
Therapeutics > Oncology > Oncology Immunotherapy
,
Therapeutics > Gene Therapy And Editing
Targeting Prostate Cancer with a Novel T-Cell Receptor and Tissue-Specific Cancer Antigens for Improved Immune Response (UCLA Case No. 2022-070)
Researchers from UCLA’s Department of Microbiology, Immunology, & Molecular Genetics (MIMG), and the department of Molecular and Medical Pharmacology have identified a set of tissue-specific antigens which have been used to isolate and characterize a group of novel T-cell receptors (TCRs) which target prostate cancer specifically. Furthermore,...
Published: 2/14/2025
|
Inventor(s):
Owen Witte
,
Zhiyuan Mao
,
Jami Witte
,
Pavlo Nesterenko
,
John Lee
Keywords(s):
Cancer
,
cancer antigen
,
Peptide
,
peptides
,
prostate cancer
,
protein
,
t-cells
Category(s):
Therapeutics
,
Therapeutics > Oncology > Oncology Immunotherapy
,
Therapeutics > Oncology
,
Therapeutics > Immunology And Immunotherapy
Antitumor activity of NKTR-214 alone or in combination with anti-PD-1 therapy in tumors resistant to anti-PD-1 (UCLA Case No. 2019-254)
UCLA researchers have discovered a therapy for anti-PD-1 resistant tumors in colon carcinoma patients. A small molecule therapeutic alone or in combination with immune-checkpoint blockade (ICB) therapy exhibits tumor remission even in sublines with mutated signalling pathways that have rendered them ICB resistant. BACKGROUND: Immunotherapy, the...
Published: 2/14/2025
|
Inventor(s):
Antoni Ribas
Keywords(s):
Colon carcinoma
,
Immune checkpoint blockade
,
Immunotherapy
,
Oncology
,
Oncology (Small Molecules, Peptides and Antibodies)
,
PD-1
,
PD-L1
,
Resistant tumors
,
Signaling pathways
,
Small molecule therapeutics
,
Tumor
Category(s):
Life Science Research Tools
,
Therapeutics > Oncology > Oncology Immunotherapy
,
Therapeutics > Oncology > Oncology (Small Molecules)
Combination of Supercharged NK with Supercharged Gamma Delta T Cells and Supercharged CD8+ T Cells and Super Charged iNKT Cells Should Eliminate Both (UCLA Case No. 2022-322)
SUMMARY: Researchers at UCLA’s School of Dentistry have developed methods and protocols for culturing and priming various immune cells into a “supercharged” phenotype. The studied cell types include NK and iNKT cells, gamma delta T cells, and CD8+ T cells. When deployed in combination, these supercharged cells were found to eliminate...
Published: 2/14/2025
|
Inventor(s):
Anahid Jewett
Keywords(s):
Category(s):
Therapeutics
,
Therapeutics > Oncology
,
Therapeutics > Oncology > Oncology Immunotherapy
2022-129 Development of Nano-Delivered CXCR4 Antagonist Carrier to Affect Tumor Microenvironment
SUMMARY: UCLA researchers in the David Geffen School of Medicine have developed a nanocarrier platform to deliver drugs that block CXCR4 directly in tumor microenvironments, with an impact on immune cell trafficking and reducing the tumor’s metastatic burden. BACKGROUND: Cancer remains among the leading causes of death worldwide, and its burden...
Published: 2/14/2025
|
Inventor(s):
Andre Nel
Keywords(s):
Category(s):
Therapeutics
,
Therapeutics > Oncology
,
Therapeutics > Oncology > Oncology Immunotherapy
2023-043: Enhanced Gamma Delta T Cells for Immunotherapy
SUMMARY: UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel platform to generate potent, high quality Vδ2 T cells at scale for use in cancer immunotherapies. BACKGROUND: With rising cases of cancer in the world, immunotherapies have emerged as a promising and potentially effective therapeutic...
Published: 2/14/2025
|
Inventor(s):
Lili Yang
Keywords(s):
Category(s):
Therapeutics
,
Therapeutics > Immunology And Immunotherapy
,
Therapeutics > Oncology
,
Therapeutics > Oncology > Oncology Immunotherapy
2022-190 Pharmacological Modulation of Chimeric Antigen Receptor (CAR)-T Cell Signaling Pathways to Improve Tumor-Killing Efficacy
SUMMARY: UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have developed a novel chimeric antigen receptor (CAR)-T cell manufacturing process to prevent premature CAR-T cell dysfunction and enhance CAR-T cell durability and potency. BACKGROUND: Chimeric antigen receptor (CAR)-T cell therapy is an emerging pillar...
Published: 2/14/2025
|
Inventor(s):
Yvonne Chen
Keywords(s):
Category(s):
Therapeutics
,
Therapeutics > Immunology And Immunotherapy
,
Therapeutics > Oncology > Oncology Immunotherapy
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