Search Results - nucleic+acid+platform+systems

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2023-021 A Ferrobotic Swarm Technology for Accessible, Adaptable, and Automated Testing

Summary: UCLA Researchers in the Department of Electrical and Computer Engineering have developed an automated, algorithm-driven nucleic acid amplification test (NAAT) method that is easy to manufacture, distribute, and yields accurate results with reduced demand of testing reagents. Background: Major epidemics over the last two decades have emerged...

Published: 8/8/2023 | Inventor(s): Dino Di Carlo, Sam Emaminejad, Haisong Lin, Wenzhuo Yu, Kiarash AmirMozafariSabet

Keywords(s): Algorithm, algorithm-based testing, automated testing, Automation, Cell Counting/Imaging, COVID-19, Ferrofluid, ferrorobotics, high throughput testing, Nanotechnology, nucleic acid amplification test (NAAT), Nucleic Acid Platform Systems, Nucleic Acids, polymerase chain reaction (PCR), pooling, Software & Algorithms, viral testing

Category(s): Software & Algorithms, Life Science Research Tools, Life Science Research Tools > Research Methods, Electrical > Electronics & Semiconductors, Diagnostic Markers, Life Science Research Tools > Cell Counting And Imaging, Platforms > Diagnostic Platform Technologies

2018-438 A DNA CONSTRUCT FOR TARGETING THERAPEUTIC MOLECULES TO DISEASED TISSUE BY IMMUNE CELLS

INTRODUCTION:UCLA researchers in the Departments of Integrative Biology & Physiology and Pathology & Laboratory Medicine have developed a novel construct for targeting therapeutic biological molecules specifically to diseased tissue, using immune cells as a delivery system. BACKGROUND:Drug delivery is the process of administering a pharmaceutical...

Published: 7/19/2023 | Inventor(s):

Keywords(s): Drug Delivery, Nucleic Acid Platform Systems, Nucleic Acids, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery > Nucleic Acid Platform Systems, Platforms > Drug Delivery > Nucleic Acids

2019-863 METHODS CONCERNING ONGOING TREATMENT FOR CANCER

UCLA researchers in the Department of Molecular, Cell, and Developmental Biology have developed a novel biomarker detection method for circulating blood cell-free RNA. BACKGROUND: Approximately 39% of men and women will be diagnosed with cancer at some point during their lifetimes. Circulating tumor cell-free DNA (cfDNA) is being increasingly used...

Published: 7/19/2023 | Inventor(s): Matteo Pellegrini, Eri Srivatsan

Keywords(s): Diagnostic Markers & Platforms, Life Science Research Tools, Nucleic Acid Platform Systems, Nucleic Acids, Oncology

Category(s): Life Science Research Tools > Plasmids/Vectors, Life Science Research Tools, Diagnostic Markers, Platforms > Drug Delivery > Nucleic Acids

2020-884 METHOD TO SEQUENCE MRNA IN SINGLE CELLS IN PARALLEL WITH QUANTIFICATION OF INTRACELLULAR PHENOTYPE

UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have developed a novel methodology that enables droplet-based, single-cell sequencing of RNA in parallel with quantification of intracellular phenotype. They performed intracellular staining with subsequent selection of T Cells expressing certain cytokine or transcription...

Published: 8/29/2023 | Inventor(s): Owen Witte, Pavlo Nesterenko, Jami Witte

Keywords(s): Nucleic Acid Platform Systems, Therapeutics & Vaccines

Category(s): Therapeutics > Oncology

2015-826 SATELLITE/HELPER VIRUS-LIKE SYSTEMS FOR AMPLIFYING RNA

Case No. 2015-826SUMMARYUCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method for high protein expression levels, in situ, involving RNA-based therapeutics.BACKGROUNDThe RNA therapeutics industry is growing at a CAGR of 12% and is expected to reach $1.2 billion by 2020. These are a novel class of therapeutics,...

Published: 7/19/2023 | Inventor(s): William Gelbart, Charles Knobler, Devin Brandt, Adam Biddlecome, Richard Sportsman, Rees Garmann

Keywords(s): Drug Delivery, Life Science Research Tools, Nucleic Acid Platform Systems, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Platforms > Drug Delivery, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Therapeutics

2017-224 SHARPR-MPRA (Systematic High-Resolution Activation and Repression Profiling with Reporter-Tiling Massively Parallel Reporter Assay)

SHARPR-MPRA (Systematic High-Resolution Activation And Repression Profiling With Reporter-Tiling Massively Parallel Reporter Assay)SUMMARYUCLA researchers in the Department of Biological Chemistry have developed a method to screen hundreds to thousands of genes to identify their regulatory functions.BACKGROUNDGenetic reporter assays are used to uncover...

Published: 9/20/2023 | Inventor(s): Jason Ernst, Manolis Kellis

Keywords(s): Life Science Research Tools, Nucleic Acid Platform Systems, Nucleic Acids, Research Methods

Category(s): Life Science Research Tools > Research Methods, Life Science Research Tools, Platforms > Drug Delivery > Nucleic Acids, Platforms > Drug Delivery > Nucleic Acid Platform Systems

DARTS: Deep Learning Augmented RNA-seq Analysis of Transcript Splicing

SummaryResearchers led by Yi Xing have developed a novel deep learning algorithm to detect alternative splicing patterns in RNA-seq dataBackgroundDevelopment of genetic sequencing tools like RNA-seq has ushered in an age of big data in genomics and transcriptomics. Collective efforts like ENCODE and the Roadmap Epigenomics Project (REP) have accelerated...

Published: 7/19/2023 | Inventor(s): Yi Xing, Zijun Zhang

Keywords(s): Life Science Research Tools, Nucleic Acid Platform Systems, Research Methods, Software, Targets And Assays, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Therapeutics, Software & Algorithms > Programs

2017-773 Optimizing B Cell Epitope-Based Autoantibody Detection in Cancer Patients

Optimizing B Cell Epitope-Based Autoantibody Detection In Cancer PatientsSUMMARYUCLA researchers from the Department of Urology have invented a new approach to optimize detection of autoantibody response using Luminex microbead-based multiplex assay. This approach bypasses the difficult process of purifying whole proteins by using select combinations...

Published: 7/19/2023 | Inventor(s): Gang Zeng

Keywords(s): Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Immunotherapy, Life Science Research Tools, Nucleic Acid Platform Systems, Targets And Assays, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Therapeutics, Therapeutics > Immunology And Immunotherapy

Improvement To Retroviral Vectors Containing The Human Ubiquitin C Promoter

SummaryUCLA researchers in the Department of Molecular Biology have developed a lentiviral vector, “pCCLc-roUBC”, containing the cellular promoter from the human ubiquitin C gene (UBC), to improve transgene expression in retroviral vectors.BackgroundGene delivery into human cells is a promising way to correct or protect against genetic alterations...

Published: 7/19/2023 | Inventor(s):

Keywords(s): Drug Delivery, Gene Editing Systems, Gene Therapy, Nucleic Acid Platform Systems, Nucleic Acids, Therapeutics & Vaccines

Category(s): Platforms > Drug Delivery, Platforms > Drug Delivery > Nucleic Acid Platform Systems, Therapeutics, Therapeutics > Gene Therapy And Editing, Platforms > Drug Delivery > Nucleic Acids