Search Results - ips%2fstem+cells

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Multiwell Plate-Based Flow Culture for Improving the Quality of 3D Tissues (Case No. 2022-067)

Summary: UCLA researchers in the Department of Mechanical and Aerospace Engineering have developed a simple, innovative method for growing 3D cell cultures with improved organoid differentiation and reduced hypoxia-induced cell death. TITLE: Multiwell Plate-Based Flow Culture for Improving the Quality of 3D Tissues Background: 3D tissue culture,...

Published: 10/23/2024 | Inventor(s): Neil Lin, Marie Payne

Keywords(s): 3D Printing, Biofilm, Biomaterial 3D Printing, Biomedical Engineering, Cancer, cancer detection, Cancer Immunotherapy, Cell and tissue culture, Cell Culture, Cellular agriculture, Cultured meat, iPS/stem cells, Laminar flow, Microwell plates, organogenesis, Organoids, Personalized Pharmacotherapy, Pharmaceutical testing, Stem Cells / Regenerative Medicine, Tissue (Biology), tissue detection, Tissue Engineering, Tissue sedimentation

Category(s): Life Science Research Tools > Lab Equipment, Life Science Research Tools, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Therapeutics, Therapeutics > Oncology

2019-870 GENE EDITING OF MONOGENIC DISORDERS IN HUMAN HEMATOPOIETIC STEM CELLS (XHIM)

Researchers at the UCLA Department of Microbiology, Immunology & Molecular Genetics have developed novel methods to achieve efficient, precise gene integration and effective expression of cDNA cassettes to express normal versions of genes in hematopoietic stem cells. BACKGROUND:Hematopoietic stem cells (HSCs)—stem cells that give rise to...

Published: 11/15/2024 | Inventor(s): Donald Kohn

Keywords(s): Gene Editing Systems, Gene Therapy, Genetic Disease, Hematology, Immunotherapy, iPS/stem cells, Therapeutics & Vaccines, Viral Delivery Systems

Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Hematology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2020-443 A PATCH OF DETACHABLE HYBRID MICRONEEDLE DEPOT (D-HMND) FOR LOCALIZED DELIVERY OF MESENCHYMAL STEM CELLS IN REGENERATION THERAPY

UCLA researchers in the Department of Bioengineering have developed a novel detachable hybrid microneedle depot (d-HMND) for the targeted delivery of mesenchymal stem cells. BACKGROUND: Stem cell biology has been widely applied to the treatment of tissue damage, due to the ability of stem cells to form, repair, and maintain tissues and organs after...

Published: 7/19/2023 | Inventor(s): Ali Khademhosseini

Keywords(s): iPS/stem cells, Life Science Research Tools, Stem Cells / Regenerative Medicine, Therapeutics & Vaccines

Category(s): Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2017-657: Gene Editing Stem Cells for Generating Non-Alloreactive T Cells for Immunotherapy

SUMMARY UCLA researchers in the Department of Pathology and Medicine have developed human stem cells that can be used to generate non-alloreactive, antigen specific T cells for adoptive cell therapy. BACKGROUND Adoptive cell therapy (ACT) with engineered T cells has shown unprecedented potential in the treatment of cancer, infectious diseases,...

Published: 9/5/2023 | Inventor(s): Gay Crooks, Christopher Seet, Amelie Montel Hagen

Keywords(s): Gene Editing Systems, Gene Therapy, iPS/stem cells, Life Science Research Tools, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Therapeutics, Therapeutics > Gene Therapy And Editing, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

From Teeth to Hearing: A Promising Source of Stem Cells for Sensorineural Hearing Loss Treatment (Case No. 2020-135)

SUMMARY: UCLA researchers in the Department of Dentistry have identified a novel source of stem cells that selectively differentiate towards auditory progenitors under appropriate conditions, for the treatment of both acute and chronic sensorineural hearing loss. BACKGROUND: Hearing loss is the most prevalent sensory disability in humans....

Published: 9/26/2023 | Inventor(s): Alireza Moshaverinia, Sevda Pouraghaei Sevari

Keywords(s): Cns, iPS/stem cells, Life Science Research Tools, Medical Devices and Materials, Therapeutics & Vaccines

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2018-470 NOVEL SOURCES OF HEMATOPOIETIC PROGENITOR CELLS

Novel Sources of Hematopoietic Progenitor CellsTech ID: 30298 / UC Case 2018-470-0SUMMARYUCLA researchers in the Department of Urology have developed a novel method of collecting hematopoietic stem cells from deceased donors that preserves the donor body and organs for further donations.BACKGROUNDHematopoietic stem cell (HSC) transplantation is growing...

Published: 7/19/2023 | Inventor(s): Jeffrey Veale, Neil Kogut, Thomas Mone

Keywords(s): Hematology, iPS/stem cells, Life Science Research Tools

Category(s): Life Science Research Tools, Therapeutics > Hematology, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2004-084 Adipose Derived Stem Cells for Reconstruction of the Urinary Tract

Stem Cell Urinary Tract Reconstruction TherapySUMMARYResearchers from the UCLA Department of Urology have successfully harvested stem cells from adipose tissue and differentiate them into functioning smooth muscle cells. These adipose derived stem cells can then be used for reconstruction or tissue engineering of smooth muscle containing organs, especially...

Published: 7/19/2023 | Inventor(s): Benjamin Wu, Larissa Rodriguez

Keywords(s): iPS/stem cells, Renal, Stem Cells / Regenerative Medicine, Urology

Category(s): Therapeutics > Urology, Therapeutics > Renal, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

Stem Cell-Derived Exosomes for the Treatment of Corneal Scarring (UCLA Case No. 2017-838)

UCLA researchers in the Department of Ophthalmology have developed a novel method to heal corneal scarring using exosomes from immortalized corneal stem cells.BACKGROUNDCorneal stromal scarring is the leading cause of corneal blindness, the second most common type of blindness globally. The current options to restore vision are corneal transplantation...

Published: 2/14/2024 | Inventor(s): Sophie Deng, James Funderburgh

Keywords(s): iPS/stem cells, Life Science Research Tools, Medical Devices and Materials, Ophthalmology

Category(s): Life Science Research Tools, Medical Devices, Therapeutics > Ophthalmology, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2016-518: Inhibition of Protein Tyrosine Phosphatase-Sigma for Hematopoietic Regeneration

Inhibition Of Protein Tyrosine Phosphatase - Sigma For Hematopoietic RegenerationSUMMARYUCLA Researchers have identified a novel pharmacological target for hematopoietic stem cell regeneration. They have developed small molecule inhibitors against the target and shown that the inhibitors cause rapid stem cell regeneration.BACKGROUNDDepletion of white...

Published: 7/19/2023 | Inventor(s): John Chute, Michael Jung, Emelyne Diers

Keywords(s): Autoimmune, Hematology, Inflammatory Diseases, iPS/stem cells, Oncology

Category(s): Therapeutics > Autoimmune, Therapeutics > Oncology, Therapeutics > Hematology, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells

2017-217 Three-step Method for Universal Enrichment, Expansion, and Maturation of Skeletal Muscle Cells Derived from Human Pluripotent Stem Cells

Three-Step Method For Universal Enrichment, Expansion, And Maturation Of Skeletal Muscle Cells Derived From Human Pluripotent Stem CellsSUMMARYUCLA researchers have developed a novel method for enriching, expanding, and maturing populations of skeletal muscle progenitor cells (SMPCs) from human pluripotent stem cells (hPSCs).BACKGROUNDSkeletal muscle...

Published: 7/19/2023 | Inventor(s): April Pyle, Michael Hicks

Keywords(s): Cell Lines, Gene Therapy, iPS/stem cells, Life Science Research Tools, Musculoskeletal Disease, Research Methods, Therapeutics & Vaccines

Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Cell Lines, Therapeutics, Therapeutics > Musculoskeletal Disease, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells, Therapeutics > Gene Therapy And Editing

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